Arsenal will be lacking the added boost of playing the second leg of their Champions League showdown with Real Madrid at home.
The Gunners were knocked out of the competition at this stage last season after losing the second leg away to Bayern Munich.
And that's far from unusual - with history proving home sides in the return fixture enjoy an advantage in their bids to progress.
During the latter stages of the Champions League, second-legs are the matches that carry the larger jeopardy with elimination a possibility, meaning the role played by having the support and familiarity of playing at home in front of fans can't be understated.
Arsenal guaranteed that factor for their last-16 win over PSV, having finished third in the league phase of the revamped competition.
It ultimately proved redundant after the Gunners won the first-leg away 7-1, but that's where their home advantage has ended.
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Madrid eliminated rivals Atletico on enemy turf in a penalty shootout, having qualified via the play-off round.
In a bizarre twist of events, Los Blancos have now been rewarded with playing the second-leg of the quarter-finals in Spain.
Why are Arsenal playing at home first?
Unfortunately for Mikel Arteta, Arsenal will not play another Champions League second leg at home this season.
The north Londoners' reward for securing a top-eight finish in the league phase was guaranteed entry to the last-16, where they would play the second-leg at the Emirates.
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That privilege doesn't extend into the latter stages of the knockouts, with UEFA already drawing the bracket to the 2024/25 final.
A randomised draw that took place when the Gunners' last-16 opponents were decided that they will play both the quarter-final and semi-final, should they make it, at home first.
That means that should Arsenal overcome Madrid, one of Aston Villa or Paris Saint-Germain will still have home advantage in the last-four.
90mins's Martin Keown, who was at the draw with the Arsenal delegation, has already raised his concerns with the format.
"When this draw was done, they sort of… I did argue with the guy who put the rules together," said Keown to football.london.
"There needs to be some benefit of getting out of the blocks early and finishing in the top eight or your league position.
"I like the fact that you play second. The last 16, the teams that didn't play in the 32, they played the home game last. There's a lot in that.
"Atletico Madrid have got that against Real Madrid. That could be quite telling. I don't think the competition organisers realise the full impact that has. In fact, they did say to me that Dortmund would probably want to play their [home] leg first. Well, that's okay then.
"But I think that the league position, one of the mistakes I'd like to offer up is they should have allowed that where you finished in the league gives you the right to play the last game at home throughout the tournament. To just draw that out of a hat in the last draw and give that away, it was a very cheap thing to do, really.
"It takes it away from what is a Champions League competition, after all, and we should be reverting back to the league right the way through the competition."
Arteta has already experienced both ends of the UEFA rule, having eliminated Porto in the last-16 by playing the second-leg at home.
Despite trailing from the first leg in Portugal, Arsenal drew level via Leandro Trossard at the Emirates, and then had their own fans to help them edge a penalty shootout victory.
One round later, the club suffered the reverse fate after losing to Bayern Munich - having only managed to draw 2-2 in the first-leg.
